E-resources
-
Lee, June-Yong; Hall, Jason A.; Kroehling, Lina; Wu, Lin; Najar, Tariq; Nguyen, Henry H.; Lin, Woan-Yu; Yeung, Stephen T.; Silva, Hernandez Moura; Li, Dayi; Hine, Ashley; Loke, P’ng; Hudesman, David; Martin, Jerome C.; Kenigsberg, Ephraim; Merad, Miriam; Khanna, Kamal M.; Littman, Dan R.
Cell, 01/2020, Volume: 180, Issue: 1Journal Article
Lymphoid cells that produce interleukin (IL)-17 cytokines protect barrier tissues from pathogenic microbes but are also prominent effectors of inflammation and autoimmune disease. T helper 17 (Th17) cells, defined by RORγt-dependent production of IL-17A and IL-17F, exert homeostatic functions in the gut upon microbiota-directed differentiation from naive CD4+ T cells. In the non-pathogenic setting, their cytokine production is regulated by serum amyloid A proteins (SAA1 and SAA2) secreted by adjacent intestinal epithelial cells. However, Th17 cell behaviors vary markedly according to their environment. Here, we show that SAAs additionally direct a pathogenic pro-inflammatory Th17 cell differentiation program, acting directly on T cells in collaboration with STAT3-activating cytokines. Using loss- and gain-of-function mouse models, we show that SAA1, SAA2, and SAA3 have distinct systemic and local functions in promoting Th17-mediated inflammatory diseases. These studies suggest that T cell signaling pathways modulated by the SAAs may be attractive targets for anti-inflammatory therapies. Display omitted •SAAs direct a distinct Th17 cell differentiation program independently of TGF-β•Expression of SAAs is associated with inflamed colon of IBD patients•Systemic SAAs in serum promote differentiation of pathogenic Th17 cells•Local SAA expression fuels pathogenicity of activated Th17 cells Serum amyloid A proteins dictate the balance between homeostatic and inflammatory Th17 cells.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.