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Zhernakova, Alexandra; Kurilshikov, Alexander; Bonder, Marc Jan; Tigchelaar, Ettje F.; Schirmer, Melanie; Vatanen, Tommi; Mujagic, Zlatan; Vila, Arnau Vich; Falony, Gwen; Vieira-Silva, Sara; Wang, Jun; Imhann, Floris; Brandsma, Eelke; Jankipersadsing, Soesma A.; Joossens, Marie; Cenit, Maria Carmen; Deelen, Patrick; Swertz, Morris A.; study, LifeLines cohort; Weersma, Rinse K.; Feskens, Edith J. M.; Netea, Mihai G.; Gevers, Dirk; Jonkers, Daisy; Franke, Lude; Aulchenko, Yurii S.; Huttenhower, Curtis; Raes, Jeroen; Hofker, Marten H.; Xavier, Ramnik J.; Wijmenga, Cisca; Fu, Jingyuan
Science (American Association for the Advancement of Science), 04/2016, Volume: 352, Issue: 6285Journal Article
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions.
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