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Koc, Özgür M; Damoiseaux, Jan; van Loo, Inge H.M.; Masquillier, Heloise I.L.; Oude Lashof, Astrid M.L.
Vaccine, 01/2020, Volume: 38, Issue: 2Journal Article
We describe a delayed hepatitis B seroprotection 12 weeks after the primary vaccination schedule in a 57-year-old male with smoldering multiple myeloma. Based on undetectable anti-HBs antibodies 6 weeks after the third vaccination, the index person was previously considered to be a hepatitis B vaccine non-responder. Because hepatitis B vaccination started in the 1980s, many hepatitis B vaccine non-responders have received a revaccination regimen. If more cases of genuine delayed hepatitis B seroprotection surface in patients with hematologic malignancies, delayed seroprotection should be considered before the commencement of hepatitis B revaccination.
