Rotenone impairs autophagic flux and lysosomal functions in Parkinson’s disease

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Rotenone impairs autophagic flux and lysosomal functions in Parkinson’s disease

Wu, F; Xu, H.-D; Guan, J.-J; Hou, Y.-S; Gu, J.-H; Zhen, X.-C; Qin, Z.-H

Neuroscience, 01/2015, Volume: 284

Journal Article

Highlights • Rotenone increased accumulation and aggregation of alpha-synuclein. • Rotenone impaired autophagy flux. • Rotenone induced lysosomal dysfunction. • Trehalose reduced rotenone-induced lysosomal damage.

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