This analysis reports an unsteady and incompressible flow of Williamson nanoliquid in presence of variable thermal characteristics are persuaded by a permeable stretching cylinder. The flow field investigation is established with the effect of mixed convection and non-uniform heat source/sink on flow and heat transfer. On the cylinder surface, the analysis is inspected with utilization of zero mass flux constraints. By using the appropriate similarity variables, the framed equations for the energy, momentum and mass is converted into non-linear ODEs. The numerical communication of the boundary value problem is successfully implemented using a computer algorithm programmed into the fifth Runge-Kutta scheme. Additionally, the wall shear factor and rate of heat transfer are calculated in two different cases namely, with curvature and without curvature. In addition, the results obtained are confirmed by making comparisons with previously published articles and we found an excellent match that guarantees the indemnity of current communication. A comprehensive change in velocity, temperature and concentration is examined for involved parameters like local Weissenberg number, space dependent heat source constant, magnetic number, curvature constant, thermophoretic parameter, buoyancy parameter, Brownian motion parameter, Prandtl number, Schmidt number, unsteadiness parameter, reaction rate parameter, activation energy parameter and temperature difference parameter. A reduction in velocity is observed for unsteady parameter and buoyancy constant. An enhanced nanofluid temperature is noted for space dependent heat source parameter, time dependent heat source parameter and unsteady parameter. Moreover, the nanofluid concentration is increases for temperature difference parameter while reverse observations are noticed for chemical reaction rate.