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Wang, Ying; Liu, Jun; Ma, Xiaowei; Cui, Chao; Deenik, Philip R; Henderson, Paul K P; Sigler, Ashton L; Cui, Lina
Scientific reports, 02/2019, Volume: 9, Issue: 1Journal Article
Detection of cellular senescence is important not only in the study of senescence in various biological systems, but also in various practical applications such as image-guided surgical removal of senescent cells, as well as the monitoring of drug-responsiveness during cancer therapies. Due to the lack of suitable imaging probes for senescence detection, particularly in living subjects, we have developed an activatable near-infrared (NIR) molecular probe with far-red excitation, NIR emission, and high "turn-on" ratio upon senescence-associated β-galactosidase (SABG) activation. We present here the first successful demonstration of NIR imaging of DNA damage-induced senescence both in vitro and in human tumor xenograft models.
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