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Uchida, Toyoaki; Shoji, Sunao; Nakano, Mayura; Hongo, Satoko; Nitta, Masahiro; Murota, Akiko; Nagata, Yoshihiro
International journal of urology, November 2009, Volume: 16, Issue: 11Journal Article
Objective: To report on the long‐term results of high‐intensity focused ultrasound in the treatment of localized prostate cancer. Methods: A total of 517 men with stage T1c–T3N0M0 prostate cancer treated with Sonablate devices (Focus Surgery, Indianapolis, IN, USA) between January 1999 and December 2007 were included in the study. Biochemical failure was defined according to the Phoenix definition (prostate‐specific antigen nadir + 2 ng/mL). Results: The median follow‐up period for all patients was 24.0 months (range, 2 to 88). The biochemical disease‐free rate (BDFR) in all patients at 5 years was 72%. The BDFR in patients with stage T1c, T2a, T2b, T2c and T3 groups at 5 years were 74%, 79%, 72%, 24% and 33%, respectively (P < 0.0001). BDFR in patients in the low, intermediate and high‐risk groups at 5 years were 84%, 64% and 45%, respectively (P < 0.0001). The BDFR in patients treated with or without neoadjuvant hormonal therapy at 7 years were 73% and 53% (P < 0.0001), respectively. In multivariate analysis, pretreatment prostate‐specific antigen levels (hazard ratio 1.060; P < 0.0001; 95% confidence interval 1.040–1.080), neoadjuvant hormonal therapy (hazard ratio 2.252; P < 0.0001; 95% confidence interval 1.530–3.315) and stage (P = 0.0189) were demonstrated to be statistically significant variables. Postoperative erectile dysfunction was noted in 33 out of 114 (28.9%) patients who were preoperatively potent. Conclusions: High‐intensity focused ultrasound therapy appears to be minimally invasive, efficacious and safe for patients with localized prostate cancer, particularly those with low‐ and intermediate‐risk cancer.
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