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Florentino, Pilar T. V.; Alves, Flávia J. O.; Cerqueira-Silva, Thiago; Oliveira, Vinicius de Araújo; Júnior, Juracy B. S.; Jantsch, Adelson G.; Penna, Gerson O.; Boaventura, Viviane; Werneck, Guilherme L.; Rodrigues, Laura C.; Pearce, Neil; Barral-Netto, Manoel; Barreto, Mauricio L.; Paixão, Enny S.
Nature communications, 08/2022, Volume: 13, Issue: 1Journal Article
Abstract Although severe COVID-19 in children is rare, they may develop multisystem inflammatory syndrome, long-COVID and downstream effects of COVID-19, including social isolation and disruption of education. Data on the effectiveness of the CoronaVac vaccine is scarce during the Omicron period. In Brazil, children between 6 to 11 years are eligible to receive the CoronaVac vaccine. We conducted a test-negative design to estimate vaccine effectiveness using 197,958 tests from January 21, 2022, to April 15, 2022, during the Omicron dominant period in Brazil among children aged 6 to 11 years. The estimated vaccine effectiveness for symptomatic infection was 39.8% (95% CI 33.7–45.4) at ≥14 days post-second dose. For hospital admission vaccine effectiveness was 59.2% (95% CI 11.3–84.5) at ≥14 days. Two doses of CoronaVac in children during the Omicron period showed low levels of protection against symptomatic infection, and modest levels against severe illness.
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