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Duong, Huong Thi; Moles, Jean-Pierre; Pham, Khue Minh; Vallo, Roselyne; Hoang, Giang Thi; Vu, Vinh Hai; Khuat, Oanh Thi Hai; Nham, Thanh Tuyet Thi; Nguyen, Duc Quang; Quillet, Catherine; Rapoud, Delphine; Van de Perre, Philippe; Castellani, Joëlle; Feelemyer, Jonathan; Michel, Laurent; Laureillard, Didier; Jarlais, Don Des; Nagot, Nicolas
The Lancet regional health. Western Pacific, 10/2022, Volume: 27Journal Article
BackgroundIn most low-to-middle-income countries, HIV control at the population level among people who inject drugs (PWID) remains a major challenge. We aimed to demonstrate that an innovative intervention can identify HIV-positive PWID in the community who are not treated efficiently, and get them treated efficiently. MethodsBetween 2016 and 2020, we implemented an intervention consisting of mass HIV screening of PWID using three annual respondent-driven sampling surveys (RDSS) and a post-intervention evaluation RDSS in community-based organisation (CBO) sites, coupled with peer support to facilitate/improve access to antiretroviral and methadone therapy in Haiphong, Vietnam. The primary outcome was the proportion of identified uncontrolled HIV-positive PWID who achieved viral control. We also estimated the potential effect of the intervention on the proportion of PWID with HIV RNA >1000 copies/mL among all PWID during the study period. FindingsOver the three RDSS, 3150 different PWID were screened, i.e. two-thirds of the estimated population size. They all injected heroin, their median age was of 39 years, 95% were male, 26.5% were HIV-infected, and 78.6% of the latter had HIV RNA ≤1000 copies/mL. Among the 177 PWID identified with an unsuppressed viral load, 73 (41.2%) achieved viral suppression at the final visit. HIV viremia decreased from 7.2% at baseline to 2.9% at the final RDSS (p<0.001). Up to 42% of this observed reduction may be explained by the intervention, in the absence of any external intervention targeting PWID during the study period. InterpretationMass community-based screening using RDSS coupled with CBO support is a powerful tool to rapidly identify untreated HIV-positive PWID and (re)link them to care. FundingNIDA (USA) and ANRS (France).
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