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Nishide, Masayuki; Nishimura, Kei; Matsushita, Hiroaki; Edahiro, Ryuya; Inukai, Sachi; Shimagami, Hiroshi; Kawada, Shoji; Kato, Yasuhiro; Kawasaki, Takahiro; Tsujimoto, Kohei; Kamon, Hokuto; Omiya, Ryusuke; Okada, Yukinori; Hattori, Kunihiro; Narazaki, Masashi; Kumanogoh, Atsushi
Nature communications, 10/2023, Volume: 14, Issue: 1Journal Article
Abstract The immunological basis of the clinical heterogeneity in autoimmune vasculitis remains poorly understood. In this study, we conduct single-cell transcriptome analyses on peripheral blood mononuclear cells (PBMCs) from newly-onset patients with microscopic polyangiitis (MPA). Increased proportions of activated CD14 + monocytes and CD14 + monocytes expressing interferon signature genes (ISGs) are distinctive features of MPA. Patient-specific analysis further classifies MPA into two groups. The MPA-MONO group is characterized by a high proportion of activated CD14 + monocytes, which persist before and after immunosuppressive therapy. These patients are clinically defined by increased monocyte ratio in the total PBMC count and have a high relapse rate. The MPA-IFN group is characterized by a high proportion of ISG + CD14 + monocytes. These patients are clinically defined by high serum interferon-alpha concentrations and show good response to immunosuppressive therapy. Our findings identify the immunological phenotypes of MPA and provide clinical insights for personalized treatment and accurate prognostic prediction.
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