In the Variable Cost and Size Bin Packing Problem with optional items, a set of items characterized by volume and profit and a set of bins of different types characterized by volume and cost are given. The goal consists in selecting those items and bins which optimize an objective function which combines the cost of the used bins and the profit of the selected items. We propose two methods to tackle the problem: branch-and-price as an exact method and beam search as a heuristics, derived from the branch-and-price. Our branch-and-price method is characterized by a two level branching strategy. At the first level the branching is performed on the number of available bins for each bin type. At the second level it consists on pairs of items which can or cannot be loaded together. Exploiting the branch-and-price skeleton, we then present a variegated beam search heuristics, characterized by different beam sizes. We finally present extensive computational results which show a high accuracy of the exact method and a very good efficiency of the proposed heuristics.