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Suo, Chenqu; Dann, Emma; Goh, Issac; Jardine, Laura; Kleshchevnikov, Vitalii; Park, Jong-Eun; Botting, Rachel A; Stephenson, Emily; Engelbert, Justin; Tuong, Zewen Kelvin; Polanski, Krzysztof; Yayon, Nadav; Xu, Chuan; Suchanek, Ondrej; Elmentaite, Rasa; Domínguez Conde, Cecilia; He, Peng; Pritchard, Sophie; Miah, Mohi; Moldovan, Corina; Steemers, Alexander S; Mazin, Pavel; Prete, Martin; Horsfall, Dave; Marioni, John C; Clatworthy, Menna R; Haniffa, Muzlifah; Teichmann, Sarah A
Science (American Association for the Advancement of Science), 06/2022, Volume: 376, Issue: 6597Journal Article
Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues combining single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics to reconstruct the developing human immune system. This revealed the late acquisition of immune-effector functions by myeloid and lymphoid cell subsets and the maturation of monocytes and T cells before peripheral tissue seeding. Moreover, we uncovered system-wide blood and immune cell development beyond primary hematopoietic organs, characterized human prenatal B1 cells, and shed light on the origin of unconventional T cells. Our atlas provides both valuable data resources and biological insights that will facilitate cell engineering, regenerative medicine, and disease understanding.
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