E-resources
-
Pozzetto, Bruno; Legros, Vincent; Djebali, Sophia; Barateau, Véronique; Guibert, Nicolas; Villard, Marine; Peyrot, Loïc; Allatif, Omran; Fassier, Jean-Baptiste; Massardier-Pilonchéry, Amélie; Brengel-Pesce, Karen; Yaugel-Novoa, Melyssa; Denolly, Solène; Boson, Bertrand; Bourlet, Thomas; Bal, Antonin; Valette, Martine; Andrieu, Thibault; Lina, Bruno; Cosset, François-Loïc; Paul, Stéphane; Defrance, Thierry; Marvel, Jacqueline; Walzer, Thierry; Trouillet-Assant, Sophie
Nature, 12/2021, Volume: 600, Issue: 7890Journal Article
Following severe adverse reactions to the AstraZeneca ChAdOx1-S-nCoV-19 vaccine , European health authorities recommended that patients under the age of 55 years who received one dose of ChAdOx1-S-nCoV-19 receive a second dose of the Pfizer BNT162b2 vaccine as a booster. However, the effectiveness and the immunogenicity of this vaccination regimen have not been formally tested. Here we show that the heterologous ChAdOx1-S-nCoV-19 and BNT162b2 combination confers better protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than the homologous BNT162b2 and BNT162b2 combination in a real-world observational study of healthcare workers (n = 13,121). To understand the underlying mechanism, we conducted a longitudinal survey of the anti-spike immunity conferred by each vaccine combination. Both combinations induced strong anti-spike antibody responses, but sera from heterologous vaccinated individuals displayed a stronger neutralizing activity regardless of the SARS-CoV-2 variant. This enhanced neutralizing potential correlated with increased frequencies of switched and activated memory B cells that recognize the SARS-CoV-2 receptor binding domain. The ChAdOx1-S-nCoV-19 vaccine induced a weaker IgG response but a stronger T cell response than the BNT162b2 vaccine after the priming dose, which could explain the complementarity of both vaccines when used in combination. The heterologous vaccination regimen could therefore be particularly suitable for immunocompromised individuals.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.