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Ren, Zhongxiang; Xu, Yetong; Li, Tiejun; Sun, Weizhong; Tang, Zhiru; Wang, Yongsheng; Zhou, Kaifeng; Li, Jigang; Ding, Qi; Liang, Kaiyang; Wu, Liuting; Yin, Yulong; Sun, Zhihong
Animal Nutrition, 09/2022, Volume: 10Journal Article
Nicotinamide adenine dinucleotide (NAD+) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD+ precursors or inhibition of NAD+-depleting enzymes can promote mitochondrial oxidative phosphorylation and improve host energy utilization efficiency. In addition, increasing evidence indicates that the gut microbiota plays a pivotal role in host metabolism. Theoretically, there should be a close correlation among NAD+, gut microbiota, and host metabolism; however, the information is limited. In this review, we summarize the metabolic process of NAD+ and its impact on host metabolism, the link between gut microbiota and host metabolism, as well as the potential effects of NAD+ on microbial metabolism, providing a new perspective on the interaction between gut microbiota and host metabolism.
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