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Jia, Longfei; Qiu, Qiongqiong; Zhang, Heng; Chu, Lan; Du, Yifeng; Zhang, Jiewen; Zhou, Chunkui; Liang, Furu; Shi, Shengliang; Wang, Shan; Qin, Wei; Wang, Qi; Li, Fangyu; Wang, Qigeng; Li, Yan; Shen, Luxi; Wei, Yiping; Jia, Jianping
Alzheimer's & dementia, August 2019, 2019-08-00, 20190801, Volume: 15, Issue: 8Journal Article
Neuronal-derived exosomal Aβ42, T-tau, and P-T181-tau have been demonstrated to be biomarkers of Alzheimer's disease (AD). However, no study has assessed the association of Aβ42, T-tau, and P-T181-tau between exosomes and CSF. This was a multicenter study with two-stage design. The subjects included 28 AD patients, 25 aMCI patients, and 29 controls in the discovery stage; the results of which were confirmed in the validation stage (73 AD, 71 aMCI, and 72 controls). The exosomal concentrations of Aβ42, T-tau, and P-T181-tau in AD group were higher than those in aMCI and control groups (all P < .001). The level of each exosomal biomarker was highly correlated with that in CSF. This study verified the agreement between CSF and blood exosomal biomarkers and confirmed that exosomal Aβ42, T-tau, and P-T181-tau have the same capacity as those in CSF for the diagnosis of AD and aMCI.
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