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Taddei, Stefano; Tsabedze, Nqoba; Tan, Ru-San
Current medical research and opinion, 2024, Volume: 40, Issue: sup1Journal Article
β-blockers are a heterogeneous class, with individual agents distinguished by selectivity for β - vs. β - and α-adrenoceptors, presence or absence of partial agonist activity at one of more β-receptor subtype, presence or absence of additional vasodilatory properties, and lipophilicity, which determines the ease of entry the drug into the central nervous system. Cardioselectivity (β -adrenoceptor selectivity) helps to reduce the potential for adverse effects mediated by blockade of β -adrenoceptors outside the myocardium, such as cold extremities, erectile dysfunction, or exacerbation of asthma or chronic obstructive pulmonary disease. According to recently updated guidelines from the European Society of Hypertension, β-blockers are included within the five major drug classes recommended as the basis of antihypertensive treatment strategies. Adding a β-blocker to another agent with a complementary mechanism may provide a rational antihypertensive combination that minimizes the adverse impact of induced sympathetic overactivity for optimal blood pressure-lowering efficacy and clinical outcomes benefit.
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