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Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt FormersAngevine, Devin J.; Camacho, Kristine Joy; Zhang, Xiaotong; Rzayev, Javid; Benedict, Jason B.
ACS omega, 05/2023, Volume: 8, Issue: 17Journal Article
Crystallization of nicotine, an oil prone to degradation at room temperature, has been demonstrated to be an effective means of creating nicotine-based materials with tunable thermal properties and improved resistance to photo-induced degradation. Herein, we show that both isomers of enantiomerically pure tartaric acid are highly effective salt formers when combined with nicotine. Both salts exhibit enhanced photostability, and with a melting point of 143.1 °C, the salt prepared using d-(−)-tartaric acid possesses one of the highest melting points for a crystalline nicotine solid reported to date.
