Modes of cancer cell invasion and the role of the microenvironment

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Modes of cancer cell invasion and the role of the microenvironment

Clark, Andrew G; Vignjevic, Danijela Matic

Current opinion in cell biology, 10/2015, Volume: 36

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Highlights • The first step in metastasis is invasion of tumor cells into the stroma. • Stromal collagen is dramatically remodeled during tumor progression. • Tumor cells can invade the stroma as single cells or collectively. • The microenvironment influences the mode and dynamics of cancer cell migration.

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Clark, Andrew G | Vignjevic, Danijela Matic

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