Involvement of l-lactate in hippocampal dysfunction of type I diabetes

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Involvement of l-lactate in hippocampal dysfunction of type I diabetes

Kobayashi, Riho; Maruoka, Junya; Norimoto, Hiroaki; Ikegaya, Yuji; Kume, Kazuhiko; Ohsawa, Masahiro

Journal of pharmacological sciences 141, Issue: 1

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Hippocampal neurons play a crucial role in memory formation. Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the amplitude of SW-Rs in diabetic mice were smaller than control group and were rescued by acute application of l-lactate, a major neural energy source. The cognitive impairment in diabetic mice was alleviated by intracerebroventricular l-lactate treatment. Our results suggested that l-lactate is important for hippocampal dysfunction in diabetes.

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