Archaeological areas in the mountain region of central Italy can be seriously threatened by geological hazards, and efforts are required to preserve cultural heritage. The Lucus Angitiae is a pre-Roman site located along the western edge of the Fucino Basin, the largest continental depression of central Apennines. The carbonate slope overhanging the area is affected by active rockfall processes from two main rock escarpments. In this paper, rockfall assessment was pursued through a 3D kinematic modelling, performed by adopting a probabilistic approach. Specific attention was dedicated to the choice and calibration of the input data, based on field evidence and a literature review. Two different sizes of wedge-shaped rock blocks were identified on rock escarpments, and specific stability analyses were performed. Sensitivity analyses accounting for possible triggering factors, such as water pressure increase and seismic action, were also carried out, together with an investigation of the seismological characteristics of the area. The results of the numerical simulations were used to design effective countermeasures in the framework of a mitigation plan for protection of the archaeological site. Finally, clues of gravity-driven slope deformations at the slope scale were documented, framing the rockfall process in a wider geological scenario.