•CryoEM provides near-native structural data for diverse biomolecular complexes.•Hybrid modeling enables construction/refinement of atomic models using cryoEM data.•CryoEM-based modeling provides unique structural insight into biomolecular function. Recent advances in cryo-electron microscopy (cryoEM) have dramatically improved the resolutions at which vitrified biological specimens can be studied, revealing new structural and mechanistic insights over a broad range of spatial scales. Bolstered by these advances, much effort has been directed toward the development of hybrid modeling methodologies for the construction and refinement of high-fidelity atomistic models from cryoEM data. In this brief review, we will survey the key elements of cryoEM-based hybrid modeling, providing an overview of available computational tools and strategies as well as several recent applications.