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Mazza, Stefano; Conforti, Francesco Simone; Forzenigo, Laura Virginia; Piazza, Nicole; Bertè, Roberto; Costantino, Andrea; Fraquelli, Mirella; Coletta, Marina; Rimola, Jordi; Vecchi, Maurizio; Caprioli, Flavio
Digestive and liver disease, January 2022, 2022-Jan, 2022-01-00, 20220101, Volume: 54, Issue: 1Journal Article
the assessment of fibrosis in Crohn's disease (CD) bowel lesions helps to guide therapeutic decisions. Real-time elastography (RTE) and delayed-enhancement magnetic resonance enterography (DE-MRE) have demonstrated good accuracy in quantifying CD-related ileal fibrosis as compared with histological examination. To date no study has compared DE-MRE and RTE. we aimed to evaluate the agreement between RTE and DE-MRE on quantifying CD-related ileal fibrosis. consecutive patients with ileal or ileocolonic CD underwent RTE and DE-MRE. Ileal fibrosis was quantified by calculating the strain ratio (SR) at RTE and the 70s-7 min percentage of enhancement gain (%EG) of both mucosa and submucosa at DE-MRE. A SR ≥2 was applied to define severe fibrosis. Clinically relevant outcomes occurring at follow-up were recorded. 40 CD patients were enrolled. A significant linear correlation was observed between SR and submucosal %EG (r = 0.594, p < 0.001). Patients with severe fibrosis (SR ≥2) had significantly higher submucosal %EG values than patients with low/moderate fibrosis (median values 26.4% vs. 9.5%, p < 0.001). During a median 43.8-month follow-up relevant disease outcomes occurred more frequently in the severe-fibrosis group (75% vs. 36%, HR 5.4, 95% CI 1.2–24.6, p = 0.029). the study demonstrates an excellent agreement between RTE and DE-MRE in assessing ileal fibrosis in CD.
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