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Lu, Yang; Giri, P.K; Lei, Shan; Zheng, Juan; Li, Weisong; Wang, Ning; Chen, Xinlin; Lu, Haixia; Zuo, Zhiyi; Liu, Yong; Zhang, Pengbo
Neuroscience, 06/2017, Volume: 352Journal Article
Highlights • Pretreatment with minocycline increased neurogenesis in the SVZ and SGZ of ketamine-exposed neonatal rats. • Minocycline pretreatment reduced cells apoptosis in SVZ and SGZ, but not frontal cortex of ketamine-exposed neonatal rats. • PI3K/Akt/GSK3β signaling pathway involved in minocycline’s protection on ketamine-induced injury to PND7 rats. • Pretreatment with minocycline improved adult spatial learning and memory deficits induced by ketamine neonatal exposure.
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