Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer

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Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer

Jung, Barbara; Staudacher, Jonas J; Beauchamp, Daniel

Gastroenterology, 01/2017, Volume: 152, Issue: 1

Journal Article

Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.

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Jung, Barbara | Staudacher, Jonas J | Beauchamp, Daniel

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