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Carrington, Lauren B.; Tran, Bich Chau Nguyen; Le, Nhat Thanh Hoang; Luong, Tai Thi Hue; Nguyen, Truong Thanh; Nguyen, Phong Thanh; Van Vinh Nguyen, Chau; Nguyen, Huong Thi Cam; Vu, Trung Tuan; Vo, Long Thi; Le, Dui Thi; Vu, Nhu Tuyet; Nguyen, Giang Thi; Luu, Hung Quoc; Dang, Anh Duc; Hurst, Timothy P.; O’Neill, Scott L.; Tran, Vi Thuy; Kien, Duong Thi Hue; Nguyen, Nguyet Minh; Wolbers, Marcel; Wills, Bridget; Simmons, Cameron P.
Proceedings of the National Academy of Sciences, 01/2018, Volume: 115, Issue: 2Journal Article
The wMel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. Here, we report that wMel-infected Ae. aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The wMel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals. This is explained by an increased susceptibility of field-reared wild-type mosquitoes to infection than laboratory-reared counterparts. Collectively, these field- and clinically relevant findings support the continued careful field-testing of wMel introgression for the biocontrol of Ae. aegypti-born arboviruses.
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