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Yang, Yong-Qiang; Li, Yun-Xia; Song, Tao; Yang, Yan-Xian; Jiang, Wei; Zhang, An-Yun; Guo, Xin-Yi; Liu, Bi-Hui; Wang, Yong-Xiang; Lei, Chang-Wei; Xiang, Rong; Wang, Hong-Ning
Antimicrobial agents and chemotherapy, 05/2017, Volume: 61, Issue: 5Journal Article
The gene was detected in 5.11% (58/1136) of isolates of chicken origin from 13 provinces in China. A novel variant, named , encoding an Ile-to-Val functional variant of MCR-1 was identified in a sequence type 155 (ST155) strain. An -containing IncI2 plasmid, pHeN867 (60,757 bp), was identified. The transfer of pHeN867 led to a 32-fold increase in the MIC of colistin in the recipient, exhibiting an effect on colistin resistance that was similar to that of .
