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Weiskopf, Daniela; Bangs, Derek J.; Sidney, John; Kolla, Ravi V.; De Silva, Aruna D.; de Silva, Aravinda M.; Crotty, Shane; Peters, Bjoern; Sette, Alessandro
Proceedings of the National Academy of Sciences - PNAS, 08/2015, Volume: 112, Issue: 31Journal Article
Dengue virus (DENV) is a rapidly spreading pathogen with unusual pathogenesis, and correlates of protection from severe dengue disease and vaccine efficacy have not yet been established. Although DENV-specific CD8⁺ T-cell responses have been extensively studied, the breadth and specificity of CD4⁺ T-cell responses remains to be defined. Here we define HLA-restricted CD4⁺ T-cell epitopes resulting from natural infection with dengue virus in a hyperepidemic setting. Ex vivo flow-cytometric analysis of DENV-specific CD4⁺ T cells revealed that the virus-specific cells were highly polarized, with a strong bias toward a CX3CR1⁺ Eomesodermin⁺ perforin⁺ granzyme B⁺ CD45RA⁺ CD4 CTL phenotype. Importantly, these cells correlated with a protective HLA DR allele, and we demonstrate that these cells have direct ex vivo DENV-specific cytolytic activity. We speculate that cytotoxic dengue-specific CD4⁺ T cells may play a role in the control of dengue infection in vivo, and this immune correlate may be a key target for dengue virus vaccine development.
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