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Guo, Y.-X; He, L.-Y; Zhang, M; Wang, F; Liu, F; Peng, W.-X
Neuroscience, 05/2016, Volume: 322Journal Article
Highlights • 1,25(OH)2 D3 enhanced Aβ1–40 brain-to-blood efflux by upregulating LRP1 expression in bEnd.3 cells under hypoxia and mice. • 1,25(OH)2 D3 reduced Aβ1–40 blood-to-brain influx by downregulating RAGE expression in bEnd.3 cells under hypoxia. • 1,25(OH)2 D3 increased Aβ1–40 peripheral uptake by upregulating LRP1 expression in HepG2 cells. • 1,25(OH)2 D3 upregulated VDR expression in mice hippocampus, bEnd.3 cells under hypoxia and HepG2 cells.
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