Purpose In recent years there has been a noticeable increase in the use of advanced hybrid closed-loop systems (AHCLs) for managing type 1 diabetes (T1D) among youth. However, there is a lack of comparison between the open-source automated insulin delivery (AID) system and the MiniMed™ 780 G system (780 G). Methods In this multi-center study, we retrospectively compared selected glycemic ranges of 26 individuals who used open-source AID and 20 individuals who used 780 G (age 11.3 years IQR 9.3, 12.9 and 13.4 years IQR 10.9, 16.5, respectively, p  = 0.069) from system initiation to the most recent visit. Results At baseline, the median HbA1c was significantly lower and the time below range (TBR) <54mg/dL was significantly higher in the open-source AID group compared to the 780 G group (6.8% IQR 6.4, 7.1 vs. 7.4% IQR 6.9, 8.6, p  = 0.006 and (1.0% IQR 0.5, 2.8 vs. 0.0% 0.0, 1.0, p  = 0.014), respectively; the median time in range (TIR 70–180mg/dL ) was similar ( p  = 0.068). After a median duration of 10.9 months on AHCLs the reduction of HbA1c was similar ( ~ 0.3%). The time spent in the hypoglycemic ranges was longer among users of the open-source AID compared to 780 G (TBR 54–70mg/dL 4.2% IQR 2.6, 7.3 vs. 2.0% 1.0, 4.0, p  = 0.005) and TBR <54mg/dL 1.1% IQR 0.4, 2.3 vs. 0.0 0.0, 1.0, p  = 0.001). Conclusions Both AHCLs similarly improved HbA1c and TIR 70–180mg/dL . The open-source AID youth had better glycemic control but spent longer time in the hypoglycemic range. These findings must be considered when choosing the use of AHCL technologies.