In this work, an innovative nanocatalyst (Cu/SiO2-Pr-NH-Benz) was synthesized and applied to coupling and click reaction in an aqueous solution. This work reports an efficient and straightforward approach for synthesizing diverse propargylamine and 1,2,3-triazole derivatives in excellent yield and short-time reaction. Also, a novel method involving the Cu NPs supported on the SiO2 nanocatalyst as a heterogeneous novel catalyst for the “one-pot” three-component A3-coupling of aldehyde, amine, and alkynes and “one-pot” click reaction between alkyne, benzyl halide, and sodium azide in the water at room temperature was developed. Significant advantageous such as enhanced catalytic activity with efficient recycling for the one-pot synthesis of 1,4-disubstituted triazoles and propargyl amine derivatives and in green condition were observed. Also, after five successive reactions, the catalytic activity of recycled Cu/SiO2-Pr-NH-Benz remained high without significant loss in its intrinsic activity. Copper nanoparticle; Multicomponent reaction; Click reaction; A3-coupling reaction, Silica nanocatalyst.