Rhizanthes is a holoparasitic plant of the Rafflesiaceae, and, just like Rafflesia , its host is Tetrastigma (Vitaceae). Unlike Rafflesia , very little research has been conducted on Rhizanthes other than a few studies focusing on its taxonomy and anatomy, and limited studies on its propagation, despite some ethnomedicinal uses in several regions of Indonesia. Wild populations of Rhizanthes are declining due to deforestation and overharvesting by locals. Artificial pollination and possible seed spread, which are similar to Rafflesia , may be useful for future propagation-based studies, which are generally very difficult and challenging for members of the Rafflesiaceae. This paper emphasizes the cultural and ethnomedicinal importance of Rhizanthes and seeks to define a conservation road-map that incorporates a scientifically-based approach to research while also seeking a four-pronged approach to the conservation of Rhizanthes : 1) conventional and biotechnology-based conservation; 2) germplasm multiplication and preservation; 3) reintroduction into the wild and conservation of wild populations; 4) policy-based protective measures.