Effects of nicotine and minor tobacco alkaloids on intracranial-self-stimulation in rats

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Effects of nicotine and minor tobacco alkaloids on intracranial-self-stimulation in rats

Harris, Andrew C; Tally, Laura; Muelken, Peter; Banal, Andrew; Schmidt, Clare E; Cao, Qing; LeSage, Mark G

Drug and alcohol dependence, 08/2015, Volume: 153

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Highlights • We tested effects of tobacco alkaloids on intracranial self-stimulation (ICSS). • Moderate nicotine doses reduced while high nicotine doses increased ICSS thresholds. • Nornicotine and anabasine produced similar effects, although with lower potency. • High-dose myosmine elevated thresholds, while anatabine and cotinine had no effect. • Some minor alkaloids can either fully or partially mimic nicotine's effects on ICSS.

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