Inspired by copper-containing enzymes such as galactose oxidase and catechol oxidase, in which distinct coordination environments and nuclearities lead to specific catalytic activities, we summarize here the catalytic properties of dinuclear and mononuclear copper species towards benzyl alcohol oxidation using a multivariate statistical approach. The new dinuclear Cu2(μ-L1)(μ-pz)2+ (1) is compared against the mononuclear CuL2Cl (2), where (L1)− and (L2)− are the respective deprotonated forms of 2,6-bis((bis(pyridin-2-ylmethyl)amino)methyl)-4-methylphenol, and 3-((bis(pyridin-2-ylmethyl)amino)methyl)-2-hydroxy-5-methylbenzaldehyde and (pz)− is a pyrazolato bridge. Copper(II) perchlorate (CP) is used as control. The catalytic oxidation of benzyl alcohol is pursued, aiming to assess the role of the ligand environment and nuclearity. The multivariate statistical approach allows for the search of optimal catalytic conditions, considering variables such as catalyst load, hydrogen peroxide load, and time. Species 1, 2 and CP promoted selective production of benzaldehyde at different yields, with only negligible amounts of benzoic acid. Under normalized conditions, 2 showed superior catalytic activity. This species is 3.5-fold more active than the monometallic control CP, and points out to the need for an efficient ligand framework. Species 2 is 6-fold more active than the dinuclear 1, and indicates the favored nuclearity for the conversion of alcohols into aldehydes. The catalytic properties of the dinuclear and mononuclear bioinspired copper species towards benzyl alcohol oxidation using a multivariate statistical approach were described. The role of the ligand environment and nuclearity were assessed. Under normalized conditions, the mononuclear compound showed superior catalytic activity. Display omitted •A new bioinspired copper complex was prepared.•Multivariate analysis was applied to the catalytic oxidation of benzyl alcohol.•The catalytic role of complexes' nuclearity and ligand framework was probed.•The mononuclear copper complex is the best catalyst.