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Sato, Mitsuo; Matsui, Akira; Shimoyama, Yoshie; Omote, Norihito; Morise, Masahiro; Hase, Tetsunari; Tanaka, Ichidai; Suzuki, Kojiro; Hasegawa, Yoshinori
Internal Medicine, 2018-Dec-01, Volume: 57, Issue: 23Journal Article
Squamous cell carcinoma (SCC) transformation has been identified as a mechanism of resistance to first-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), gefitinib or erlotinib, in EGFR-mutated lung cancer. However, whether second- or third-generation TKIs can overcome resistance due to SCC transformation remains unclear. We herein report an EGFR-mutated lung adenocarcinoma undergoing transformation into SCC that exhibited a durable response to afatinib, which is a second-generation irreversible EGFR-TKI. We suggest that afatinib can be considered as a treatment option for EGFR-mutated tumor undergoing SCC transformation, particularly in the absence of a T790M mutation.
