Protease activated receptor-1 mediates cytotoxicity during ischemia using in vivo and in vitro models

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Protease activated receptor-1 mediates cytotoxicity during ischemia using in vivo and in vitro models

Rajput, P.S; Lyden, P.D; Chen, B; Lamb, J.A; Pereira, B; Lamb, A; Zhao, L; Lei, I.-F; Bai, J

Neuroscience, 12/2014, Volume: 281

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Highlights • PAR-1 knockdown neuronal and astrocytes cells are negative for TUNEL-positive cells. • PAR-1 knockdown results in 70% reduction of dying neurons with improved neurological deficits. • Knockdown or inhibition of PAR-1 would provide neuroprotection in the brain from ischemic injury.

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