E-resources
-
Lin, Y. F.; Jing, W.; Wu, L.; Li, X. Y.; Wu, Y.; Liu, L.; Tang, W.; Long, J.; Tian, W. D.; Mo, X. M.
Cell proliferation, October 2008, Volume: 41, Issue: 5Journal Article
. Objectives: In this study, a group of cells that expressed both osteogenic and adipogenic characters was identified from murine adipose stromal cells. Materials and methods: These cells could be enriched in the Sca‐1−1 population and express both osteogenic and adipogenic genes. Osteogenic induction enhanced expression of osteogenic genes and inhibited expression of adipogenic genes, while adipogenic induction enhanced expression of adipogenic genes and inhibited expression of osteogenic genes. These cells have been called osteo–adipo progenitors (OAPs). Results: OAPs expressed transcription factor runt‐related transcription factor 2 (RUNX2) and peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) proteins in cytoplasm. When OAPs were cultured in adipogenic medium, PPAR‐γ moved to the nucleus and the cells differentiated into adipocytes, while the RUNX2 remained in the cytoplasm. In contrast, when OAPs were cultured in osteogenic medium, RUNX2 moved to the nucleus and the cells differentiated to osteocytes, while the PPAR‐γ remained in the cytoplasm. Conclusions: These experiments suggest that osteoblasts and adipocytes share a common predecessor, the OAP, in murine adipose stromal cells.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.