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Ikeuchi, Kazuhiko; Doki, Noriko; Takao, Akinari; Hishima, Tsunekazu; Yamada, Yuta; Konishi, Tatsuya; Nagata, Akihito; Takezaki, Toshiaki; Kaito, Satoshi; Kurosawa, Shuhei; Sakaguchi, Masahiro; Harada, Kaito; Yasuda, Shunichiro; Yoshioka, Kosuke; Watakabe-Inamoto, Kyoko; Igarashi, Aiko; Najima, Yuho; Muto, Hideharu; Kobayashi, Takeshi; Kakihana, Kazuhiko; Sakamaki, Hisashi; Ohashi, Kazuteru
Internal Medicine, 01/2017, Volume: 56, Issue: 23Journal Article
Extramedullary relapse (EMR) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is relatively rare. The most commonly reported sites in acute lymphoblastic leukemia (ALL) patients after allo-HSCT are soft tissue and the central nervous system, and the gastrointestinal system is an uncommon site. We herein report a unique case with massive hematemesis resulting from gastrointestinal relapse of ALL after allo-HSCT. Upper gastrointestinal endoscopy showed bleeding from a 1.5-cm submucosal tumorous lesion with central ulceration on the anterior wall of the stomach. At the same time, computed tomography revealed extramedullary relapse at the breast and bilateral adrenal glands.
