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Eilers, M.; Verner, K.; Hwang, S.; Schatz, G.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 05/1988, Volume: 319, Issue: 1193Journal Article
A mounting body of evidence suggests that cytoplasmically synthesized proteins destined to be imported into the mitochondrial interior must at least partly unfold to penetrate across the mitochondrial membranes. During post-translational import, this unfolding process appears to be a major rate-limiting step. It can be blocked by ligands that stabilize the protein’s native conformation and appears to be accompanied by the cleavage of ATP outside the mitochondrial inner membrane.
