E-resources
-
Bakker, Mark K; Spek, Rick A. A. van der; Rheenen, Wouter van; Morel, Sandrine; Bourcier, Romain; Hostettler, Isabel C; Alg, Varinder S; Eijk, Kristel R. van; Koido, Masaru; Akiyama, Masato; Terao, Chikashi; Matsuda, Koichi; Walters, Robin G; Lin, Kuang; Li, Liming; Millwood, Iona Y; Chen, Zhengming; Rouleau, Guy A; Zhou, Sirui; Rannikmae, Kristiina; Sudlow, Cathie L. M; Houlden, Henry; Berg, Leonard H. van den; Dina, Christian; Naggara, Olivier; Gentric, Jean-Christophe; Shotar, Eimad; Eugene, Francois; Desal, Hubert; Winsvold, Bendik S; Borte, Sigrid; Johnsen, Marianne Bakke; Brumpton, Ben M; Sandvei, Marie Softeland; Willer, Cristen J; Hveem, Kristian; Zwart, John-Anker; Verschuren, W. M. Monique; Friedrich, Christoph M; Hirsch, Sven; Schilling, Sabine; Dauvillier, Jerome; Martin, Olivier; Bian, Zheng; Chen, Junshi; Chen, Yiping; Clarke, Robert; Collins, Rory; Guo, Yu; Han, Xiao; Hill, Michael; Liu, Depei; Lv, Jun; Millwood, Iona; Peto, Richard; Sansome, Sam; Walters, Robin; Yang, Xiaoming; Yu, Canqing; Kamatani, Yoichiro; Redon, Richard; Sargurupremraj, Muralidharan; Tatlisumak, Turgut; Debette, Stephanie; Werring, David J; Bonner, Stephen; Walsh, Daniel; Bulters, Diederik; Kitchen, Neil; Brown, Martin; Grieve, Joan; Malik, Rainer; Dichgans, Martin; Rinkel, Gabriel J. E; Worrall, Bradford B; Pera, Joanna; Slowik, Agnieszka; Broderick, Joseph P; Woo, Daniel; Bijlenga, Philippe; Ruigrok, Ynte M; Jones, Gregory T; Bown, Matthew J; Ko, Nerissa U; Kim, Helen; Coleman, Jonathan R. I; Breen, Gerome; Zaroff, Jonathan G; Klijn, Catharina J. M; Amouyel, Philippe; Gaal-Paavola, Emilia I; Niemela, Mika; Jaaskelainen, Juha E; Fraunberg, Mikael von und zu; Lindgren, Antti; Veldink, Jan H
Nature Genetics, 01/2020Journal Article
Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits. Cross-ancestry genome-wide association analyses in individuals of European and East Asian ancestry identify 11 new risk loci for intracranial aneurysms and highlight a polygenic architecture explaining a substantial fraction of disease heritability.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.