Provider: - Institution: - Data provided by Europeana Collections- Objective: To evaluate diagnostic accuracy and efficiency of ultrasound markers of gestational diabetes (GDM) and propose an ultrasound based scoring system suitable for screening (UGDS). Methods: 132 women with singleton pregnancies and established maternal and/or pregnancy related risk factors for GDM were scanned at/or after 24 weeks gestation followed by administration of a 3 hour 100-gram oral glucose tolerance test (oGTT). A number of ultrasound markers were determined/measured, including fetal adipose subcutaneous tissue, asymmetrical macrosomy, cardiac circumference, cardiac width, and interventricular septum thickness, immature appearance of placenta, intensified breathing movements, polyhydramnios and placental thickness. Each ultrasound GDM marker was assigned one point to create the ultrasound gestational diabetes screening score (UGDS). Results: All ultrasound GDM markers were positively correlated to the disease P < 0.0001. The strongest independent predictor of GDM was an immature appearance of placenta (RR 49.09 95% CI 7,04-342,28, P < 0.0001). Receiver operator characteristics (ROC) showed an area under the curve of 96.9% confirming good ability of UGDS to discriminate between positive and negative oGTT. We propose a UGDS score of 4 providing diagnostic efficiency of 92%, sensitivity 93.2%, specificity 92%, positive predictive value 85,4% and negative predictive value 96,4%. Conclusions: This study suggests that UGDS is a good predictor of GDM. UGDS may be an adjunct to current screening tools for GDM.- Cilj: Evaluirati dijagnostičku pouzdanost i efikasnost ultrazvučnih markera gestacionog dijabetesa (GDM) i predloženog ultrazvučnog skora u otkrivanju GDM-a. Metode: 132 trudnice sa jednoplodnim trudnoćama gestacione starosti veće od 24. nedelje gestacije i prisutnim najmanje jednim faktorom rizika za GDM, bilo maternalnim ili vezanog za trudnoću, podvrgnute su ultrazvučnom pregledu, a nakon toga oralnom testu opterećenja sa 100 g glukoze (oGTT). Ultrazvučni marker mereni ili determinisani tokom pregleda su: fetalno potkožno masno tkivo, asimetrična makrozomija, obim i širina fetalnog srca, debljina interventrikularnog septuma, nezreli placentalni izgled, intenzivirani fetalni disajni pokreti, polihidramnion i placentalna debljina. Svaki od prisutnih pomenutih markera dobio je jedan poen, a u cilju formiranja ultrazvučnog skora za otkrivanje šećerne bolesti trudnica (UGDS). Rezultati: Svi ultrazvučni markeri GDM-a su pozitivno korelirani sa bolešću, P < 0.0001. Najjači nezavisni prediktor GDMa je nezreli placentalni izgled (RR 49.09 95% CI 7,04-342,28, P < 0.0001). Receiver operator characteristics (ROC) analiza demonstrirala je površinu ispod krive od 96.9%, potvrđujući dobru sposobnost UGDS-a da razlikuje patološke od normalnih vrednosti oGTT-a. Kao granična vrednost UGDS-a predložen je skor jednak ili veći od 4, koji rezultuje sveukupnom tačnošću od 92%, senzitivnošću od 93.2%, specifičnošću od 92%, pozitivnom prediktivnom vrednošću od 85,4% i negativnom prediktivnom vrednošću od 96,4%. Zaključci: Rezultati disertacije sugerišu da je UGDS dobar prediktor GDM-a. UGDS može biti dodatak trenutnim skrining metodama za detekciju GDM-a.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana