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  • Thermally induced transitions of d(▫$G_4T_4G_3$▫) quadruplexes can be described as kinetically driven processes [Elektronski vir]
    Prislan, Iztok ; Urbič, Tomaž ; Poklar Ulrih, Nataša
    DNA sequences that are rich in guanines and can form four-stranded structures are called G-quadruplexes. Due to the growing evidence that they may play an important role in several key biological ... processes, the G-quadruplexes have captured the interest of several researchers. G-quadruplexes may form in the presence of different metal cations as polymorphic structures formed in kinetically governed processes. Here we investigate a complex polymorphism of d(G4T4G3) quadruplexes at different K+ concentrations. We show that population size of different d(G4T4G3) quadruplex conformations can be manipulated by cooling rate and/or K+ concentration. We use a kinetic model to describe data obtained from DSC, CD and UV spectroscopy and PAGE experiments. Our model is able to describe the observed thermally induced conformational transitions of d(G4T4G3) quadruplexes at different K+ concentrations.
    Vir: Life [Elektronski vir]. - ISSN 2075-1729 (Vol. 12, iss. 6, [article no.] 825, Jun. 2022, str. 1-15)
    Vrsta gradiva - e-članek
    Leto - 2022
    Jezik - angleški
    COBISS.SI-ID - 110011395

    Povezava(-e):

    https://www.mdpi.com/2075-1729/12/6/825/htm
    DOI

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