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  • Mitochondria regulate the amplitude of simple and complex calcium oscillations
    Grubelnik, Vladimir ...
    In a mathematical model for simple calcium oscillations [Biophys. Chem. 71 (1998) 125], it has been shown that mitochondria play an important role in the maintenance of constant amplitudes of ... cytosolic ▫$Ca^2+$▫ oscillations. Simple plausible rate laws for ▫$Ca^2+$▫ fluxes across the inner mitochondrial membrane have been used in this model. Here we show that it is possible to use the same rate laws as a plug-in element in other existing mathematical models and obtain the same effect on amplitude regulation. This result appears to be universal, independent of the type of model and the type of ▫$Ca^2+$▫ oscillations. We demonstrate this on two models for spiking ▫$Ca^2+$▫ oscillations [J. Biol. Chem. 266 (1991) 11068; Cell Calcium 14 (1993) 311] and on two recent models for bursting ▫$Ca^2+$▫ oscillations; one of them being a receptor-operated model [Biophys. J. 79 (2000) 1188] and the other one being a store-operated model [BioSystems 57 (2000) 75]
    Vir: Biophysical chemistry. - ISSN 0301-4622 (94, 2001, str. 59-74)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2001
    Jezik - angleški
    COBISS.SI-ID - 11403016

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