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  • Dopaminergic regulation of synaptotagmin I and IV mRNAs in hemiparkinsonian rts
    Glavan, Gordana ...
    Synaptotagmins (Syts) I and IV are synaptic proteins involved in the regulation of neurosecretion. Dopaminergic drugs have been shown to modulate their expression. Here we investigate whether ... dopaminergic regulation of syt Iand syt IV expression could play a role in the hypersensitive striatum of rats with unilateral lesions of dopaminergic nigrostriatal neurons with 6hydroxydopamine. We show that chronic dopaminergic denervation resulted in a small down-regulation of striatal syt I mRNA whereas acute treatment with SKF-82958, a dopamine DI receptor agonist, induced a massive syt IV mRNA upregulation in the striatum on the lesioned side. We conclude that chronic lack of dopamine and treatment with dopamine depleted basal ganglia.
    Vir: Neuroreport. - ISSN 0959-4965 (Letn. 11, št. 18, 2000, str. 4043-4047)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 12582105

vir: Neuroreport. - ISSN 0959-4965 (Letn. 11, št. 18, 2000, str. 4043-4047)
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