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  • Tolterodin - novo zdravilo za bolnike s čezmerno aktivnim sečnim mehurjem = Tolterodine - a new drug for patients with an overactive bladder
    Tršinar, Bojan
    Background. Tolterodine is a new antimuscarinic drug for the treatment of patients with clinical symptoms and signs of overactive bladder. The objectiveof this trial was to compare the clinical ... efficacy and safety of tolterodine with that of placebo. Patients and methods. This international prospective, randomized, enrolled 21 patients. The study group (n = 11) was given tolterodine 2 mg twice daily for 12 weeks and the control group (n = 10)received placebo for the same period of time. Three days before and 3 days after the trial, micturition charts were completed by all subjects to provide the following data: number of voidings per 24 hours, urine volume voided per micturition, and number of urge incontinence episodes per 24 hours. At two control control visits, the subject were asked to report side effects of the drug. After 12 weeks' treatment, the patients' subjective assessment of the clinical efficacy of the drug was recorded. Statistical analysis was done using the Student t-test. Results. Before the study, there were no significantdifferences between the two groups concerning sex, body weight, height and micturition problems. After 12 weeks' treatment with tolterodine, volume voided per micturition increased by 25% (p < 0.05), and the number of urge incontinence episodes/24 hours declined by 47% (p < 0.05). There was a nonsignificant decrease in the frequency of micturition per 24 hours (13%). The effect of placebo was statistically negligible. Six of the 11 subjects in the study group felt that tolterodine was a very effective drug, and only one of the 10 control subjects felt the same about placebo. The most frequent adverse effect was dry mouth, reported by 5 subjects on tolterodine and 4 subjects on placebo.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 69, št. 12, december 2000, str. 813-816)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 12596697

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