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Autologous mesenchymal stem cells for treatment of chronic active antibody-mediated kidney graft rejection : report of the phase I/II clinical trial case seriesVečerić-Haler, Željka ...Mesenchymal stem cell (MSCs) therapy has already been studied in kidney transplant recipients (KTRs), and the available data showed that it is safe and well tolerated. The aim of this study was to ... evaluate the safety and efficacy of autologous MSCs in combination with standard therapy in KTRs with biopsy-proven chronic active antibody-mediated rejection (AMR). Patients with biopsy-proven chronic active AMR received treatment with autologous bone marrow-derived MSCs (3 × 106 cells/kg iv) after completion of standard therapy and were followed for up to 12 months. The primary endpoints were safety by assessment of adverse events. Secondary endpoints included assessment of kidney graft function, immunological and histological changes related to AMR activity and chronicity assessed by conventional microscopy and molecular transcripts. A total of 3 patients were enrolled in the study before it was terminated prematurely because of adverse events. We found that AMR did not improve in any of the patients after treatment with MSCs. In addition, serious adverse events were observed in one case when autologous MSCs therapy was administered in the late phase after kidney transplantation, which requires further elucidation.Vir: Transplant international. - ISSN 0934-0874 (Vol. 35, iss. , [ article no.] 10772, 2022, str. 1-10)Vrsta gradiva - članek, sestavni delLeto - 2022Jezik - angleškiCOBISS.SI-ID - 131622403
Avtor
Večerić-Haler, Željka |
Sever, Matjaž, 1976- |
Kojc, Nika |
Halloran, Philip F. |
Boštjančič, Emanuela, 1979 |
Mlinšek, Gregor |
Oblak, Manca |
Poženel, Primož, medicina |
Švajger, Urban |
Pretnar-Hartman, Katrina |
Knežević, Miomir |
Barlič, Ariana |
Girandon, Lenart |
Aleš, Andreja |
Zver, Samo, 1966- |
Buturović-Ponikvar, Jadranka |
Arnol, Miha
Teme
nefrologija |
mezenhimske matične celice |
transplantacija ledvice
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Večerić-Haler, Željka | 37833 |
Sever, Matjaž, 1976- | 24908 |
Kojc, Nika | 22462 |
Halloran, Philip F. | ![]() |
Boštjančič, Emanuela, 1979 | 25441 |
Mlinšek, Gregor | 19576 |
Oblak, Manca | 38325 |
Poženel, Primož, medicina | 35048 |
Švajger, Urban | 26198 |
Pretnar-Hartman, Katrina | 15978 |
Knežević, Miomir | 10038 |
Barlič, Ariana | 15627 |
Girandon, Lenart | 30197 |
Aleš, Andreja | 19651 |
Zver, Samo, 1966- | 23817 |
Buturović-Ponikvar, Jadranka | 10649 |
Arnol, Miha | 21624 |
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