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Brefeldin A and a synthetic peptide to ADP-ribosylation factor (ARF) inhibit regulated exocytosis in melanotrophsRupnik, Marjan ...We investigated the role of ADP-ribosylation factor (ARF) in regulated exocytosis in patch-clamped rat melanotrophs. Addition of brefeldin A (BFA) toinhibit activation of endogenous ARF protein was ... found to attenuate regulated secretory activity monitored as changes in membrane capacitance (Cm). A synthetic peptide to amino acids 46-61 of ARF (P-14) was also found toinhibit Ca(2+)-induced secretory activity in these cells. This inhibition was not apparent with a scrambled amino acid sequence of ARF-P14 peptide. Thispaper provides the first patch-clamp study to suggest that the small GTP-binding protein ARF is required to trigger release of secretory granules from rat pituitary melanotrophs.Vir: Neuroreport. - ISSN 0959-4965 (Let. 6, št. 6, 1995, str. 853-856)Vrsta gradiva - članek, sestavni delLeto - 1995Jezik - angleškiCOBISS.SI-ID - 13273
Avtor
Rupnik, Marjan |
Law, G... J. |
Northrop, A... J. |
Mason, W... T. |
Zorec, Robert, 1958-
Teme
Adenyl cyclase |
Metabolism |
Cyclopentanes |
Pharmacology |
Exocytosis |
Drug effects |
G-proteins |
Metabolism |
Pituitary gland, anterior |
Cytology |
Protein synthesis inhibitors |
Pharmacology |
Amino acid sequence |
Calcium |
Antagonists and inhibitors |
Pharmacology |
Chromatography, high pressure liquid |
Molecular sequence data |
Patch-clamp techniques |
Pituitary gland, anterior |
Drug effects |
Rats |
Animal |
Rats
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Rupnik, Marjan | 12266 |
Zorec, Robert, 1958- | 03702 |
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