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  • Dynamic kinetic resolution of β-substituted α-diketones via asymmetric transfer hydrogenation [Elektronski vir]
    Chen, Ting ...
    Developing innovative dynamic kinetic resolution (DKR) modes and achieving the highly regio- and enantioselective semihydrogenation of unsymmetrical α-diketones are two formidable challenges in the ... field of contemporary asymmetric (transfer) hydrogenation. In this work, we report the highly regio- and stereoselective asymmetric semi-transfer hydrogenation of unsymmetrical α-diketones through a unique DKR mode, which features the reduction of the carbonyl group distal from the labile stereocenter, while the proximal carbonyl remains untouched. Moreover, the protocol affords a variety of enantioenriched acyclic ketones with α-hydroxy-α′-C(sp2)-functional groups, which represent a new product class that has not been furnished in known arts. The utilities of the products have been demonstrated in a series of further transformations including the rapid synthesis of drug molecules. Density functional theory calculations and plenty of control experiments have also been conducted to gain more mechanistic insights into the highly selective semihydrogenation.
    Vir: Journal of the American Chemical Society [Elektronski vir]. - ISSN 1520-5126 (Vol. 145, iss. 1, 2023, str. 585-599)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2023
    Jezik - angleški
    COBISS.SI-ID - 136025347

    Povezava(-e):

    https://pubs.acs.org/doi/10.1021/jacs.2c11149
    DOI

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