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Empirical rescue treatment of Helicobacter pylori infection in third and subsequent lines [Elektronski vir] : 8-year experience in 2144 patients from the European Registry on H. pylori management (Hp-EuReg)Burgos-Santamaría, Diego ...Objective To evaluate the use, effectiveness and safety of Helicobacter pylori empirical rescue therapy in third and subsequent treatment lines in Europe. Design International, prospective, ... non-interventional registry of the clinical practice of European gastroenterologists. Data were collected and quality reviewed until October 2021 at Asociación Española de Gastroenterología-Research Electronic Data Capture. All cases with three or more empirical eradication attempts were assessed for effectiveness by modified intention-to-treat and per-protocol analysis. Results Overall, 2144 treatments were included: 1519, 439, 145 and 41 cases from third, fourth, fifth and sixth treatment lines, respectively. Sixty different therapies were used; the 15 most frequently prescribed encompassed >90% of cases. Overall effectiveness remained <90% in all therapies. Optimised treatments achieved a higher eradication rate than non-optimised (78% vs 67%, p<0.0001). From 2017 to 2021, only 44% of treatments other than 10-day single-capsule therapy used high proton-pump inhibitor doses and lasted ≥14 days. Quadruple therapy containing metronidazole, tetracycline and bismuth achieved optimal eradication rates only when prescribed as third-line treatment, either as 10-day single-capsule therapy (87%) or as 14-day traditional therapy with tetracycline hydrochloride (95%). Triple amoxicillin-levofloxacin therapy achieved 90% effectiveness in Eastern Europe only or when optimised. The overall incidence of adverse events was 31%. Conclusion Empirical rescue treatment in third and subsequent lines achieved suboptimal effectiveness in most European regions. Only quadruple bismuth-metronidazole-tetracycline (10-day single-capsule or 14-day traditional scheme) and triple amoxicillin-levofloxacin therapies reached acceptable outcomes in some settings. Compliance with empirical therapy optimisation principles is still poor 5 years after clinical practice guidelines update.Vir: Gut [Elektronski vir]. - ISSN 1468-3288 (Vol. 72, iss. , May 2023, str. 1054-1072)Vrsta gradiva - e-članekLeto - 2023Jezik - angleškiCOBISS.SI-ID - 140177155
Avtor
Burgos-Santamaría, Diego |
Perez Nyssen, Olga |
Gasbarrini, Antonio |
Vaira, Dino |
Perez -Aisa, Angeles |
Rodrigo Sáez, Luis |
Pellicano, Rinaldo |
Keco-Huerga, Alma |
Pabon Carrasco, Manuel |
Castro-Fernandez, Manuel |
Boltin, Doron |
Barrio, Jesús |
Phull, Perminder |
Kupcinskas, Juozas |
Jonaitis, Laimas |
Ortiz-Polo, Inmaculada |
Tepeš, Bojan
Teme
Helicobacter pylori |
antibiotic therapy |
antibiotics |
drug resistance |
proton pump inhibition |
Helicobacter pylori |
antibiotična terapija |
odpornost na zdravila |
zaviranje protonske črpalke
Vnos na polico
Trajna povezava
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Burgos-Santamaría, Diego | |
Perez Nyssen, Olga | |
Gasbarrini, Antonio | |
Vaira, Dino | |
Perez -Aisa, Angeles | |
Rodrigo Sáez, Luis | |
Pellicano, Rinaldo | |
Keco-Huerga, Alma | |
Pabon Carrasco, Manuel | |
Castro-Fernandez, Manuel | |
Boltin, Doron | |
Barrio, Jesús | |
Phull, Perminder | |
Kupcinskas, Juozas | |
Jonaitis, Laimas | |
Ortiz-Polo, Inmaculada | |
Tepeš, Bojan | 07942 |
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