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Differential regulation of proteins by bursting calcium oscillations : a theoretical studySchuster, Stefan ; Knoke, Beate ; Marhl, MarkoCalcium in ionic form is a second messenger connecting several input signals to several target processes in the cell. The question arises how one second messenger can transmit more than one signal ... simultaneously (bow-tie structure of signalling). Experimental data on calcium dynamics often show patterns of successive low-peak and high-peak ascillatory phases, known as bursting. Here, we propose that bursting calcium oscillations can perform the function of simultaneous transmission of two signals at physiological calcium concentrations, for example, by selective activation of two calcium-binding proteins. This differential regulation by periodic bursting is investigated in a theoretical model. The two proteins are assumed to be activated by calcium, and one of them is assumed to be subject to biphasic regulation due to additional inhibitory binding sites. To explore which characteristics of the complex signal could be responsible for independent regulation of low-peak activated and spike activated targets, different bursting patterns of simplified square pulses are applied. Depending on the change in the bursting pattern, one protein can be gradually activated at a constant level of the other protein's activity, or the two preteins can be activated simultaneously,or one protein can be activated while the other one is deactivated simultaneously. Thus, the two proteins can be regulated virtually independently.Vir: Biosystems. - ISSN 0303-2647 (81, 2005, str. 49-63)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2005Jezik - angleškiCOBISS.SI-ID - 14019080
Avtor
Schuster, Stefan |
Knoke, Beate |
Marhl, Marko
Teme
biofizika |
kalcijeve oscilacije |
celična dinamika |
matematični modeli |
dekodiranje |
pogostost |
biophysics |
calcium oscillations |
cellular dynamics |
mathematical models |
structure of signalling |
bursting oscillations |
decoding |
frequency encoding |
signalling proteins
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Schuster, Stefan | |
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Marhl, Marko | 13159 |
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