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13.
Dynamic antigen presentation patterns of Listeria monocytogenes-derived CD8 T cell epitopes in vivo
Škoberne, Mojca, 1972- ...
Little information exists regarding the presentation of antigenic peptides in infected tissues. In this study the in vivo presentation of four different CD8T cell epitopes of Listeria monocytogenes ...was monitored. Peptide presentation was measured by a new, highly sensitive, ex vivo Ag presentation assay that was based on the testing of freshly isolated cells from infected spleens with peptide-specific CD8 T cell lines in an IFN-gamma-specific ELISPOT assay. Remarkably, the peptide presentation pattern of splenocytes andthat of macrophages purified from spleens of L. monocytogenes-infected micewere different from those of in vitro infected macrophage-like cell lines.The in vivo Ag presentation pattern of splenocytes also exhibited dynamic changes during the first 48 h of infection. In vivo peptide presentation at later time points postinfection was biased toward immunodominant CD8 T cell epitopes, while at an early time point, 6 h postinfection, subdominant and dominant CD8 T cell epitopes were presented with similar strength. In summary, our studies show that Ag presentation during an infection is a highly dynamic process that only can be fully appreciated by the study of cells infected in their physiological environment.
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